http://gcc.gnu.org/bugzilla/show_bug.cgi?id=45375 --- Comment #202 from H.J. Lu <hjl.tools at gmail dot com> --- LTO miscompiles 435.gromacs in SPEC CPU 2006 on x32 with -mx32 -O3 -funroll-loops -ffast-math since r208165 (PR 60418). Can you try r208163?